/*muscle-invasive-safety.css*/

@import url('https://fonts.googleapis.com/css2?family=Ubuntu:ital,wght@0,300;0,400;0,500;0,700;1,300;1,400;1,500;1,700&display=swap');

#muscle-invasive__safety #safety-main-container {
    background-image: linear-gradient(180deg, rgba(228, 237, 252, 0.00) 0%, #E4EDFC 100%);
}

#muscle-invasive__safety .experiencefragment + .container {
    margin-top: 139px;
}

#muscle-invasive__safety .cmp-text {
    padding: 0;
}

#muscle-invasive__safety #safety-main-container .button + .title,
#muscle-invasive__safety #safety-main-container #grey-head,
#muscle-invasive__safety #safety-main-container #adverse-reactions .text,
#muscle-invasive__safety #safety-main-container #discontinuation-rates .text,
#muscle-invasive__safety #safety-main-container #laboratory-abnormalities .text {
    max-width: 773px;
}

#muscle-invasive__safety #safety-main-container .title,
#muscle-invasive__safety #safety-main-container .azcl-container.aem-GridColumn,
#muscle-invasive__safety #safety-main-container .aem-Grid > .container,
#muscle-invasive__safety #safety-main-container .aem-Grid >  .text:nth-child(2) {
    max-width: 888px; 
}

#muscle-invasive__safety #safety-main-container .title,
#muscle-invasive__safety #safety-main-container .aem-Grid > .title + .text,
#muscle-invasive__safety #safety-main-container #grey-head,
#muscle-invasive__safety #safety-main-container #adverse-reactions .text,
#muscle-invasive__safety #safety-main-container #discontinuation-rates .text,
#muscle-invasive__safety #safety-main-container #laboratory-abnormalities .text,
#muscle-invasive__safety #safety-main-container .azcl-container.aem-GridColumn,
#muscle-invasive__safety #safety-main-container .aem-Grid > .container {
    margin: 0 auto;
    float: none;
    display: block;
    font-family: 'Ubuntu', sans-serif;
    background: #fff;
}

#muscle-invasive__safety #safety-main-container .azcl-container.aem-GridColumn {
    margin-top: 25px;
}

#muscle-invasive__safety .title h1 {
    padding: 35px 0 0 55px;
}

#muscle-invasive__safety #grey-head p {
    font-size: 18px;
    line-height: 28px;
    font-weight: 700;
    color: #555555;
    margin: 10px 0 30px;
    font-family: 'Ubuntu';
}

#muscle-invasive__safety #grey-head p a {
    color: #003865;
    text-decoration: underline;
}

#muscle-invasive__safety #safety-main-container h2 {
    font-size: 24px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    color: #003865;
    margin: 33px 0;
}

#muscle-invasive__safety #safety-main-container .content-box {
    border: 1px solid #03315D;
    border-left: 10px solid #03315D;
    border-bottom-right-radius: 32px;
    padding: 15px;
    position: relative;
}

#muscle-invasive__safety #safety-main-container .box-title {
    font-size: 14px;
    font-style: normal;
    font-weight: 700;
    line-height: 22px;
    color: #003865;
    margin: 0;
    position: absolute;
    top: -14px;
    left: 0;
    background: #fff;
    padding: 0 10px 0 15px;
    z-index: 1;
    text-transform: uppercase;
    font-family: 'Ubuntu', sans-serif;
}

#muscle-invasive__safety #safety-main-container .box-title:before {
    content: '';
    background: #03315d;
    position: absolute;
    left: -10px;
    top: 6px;
    width: 10px;
    height: 12px;
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table {
    border-collapse: collapse;
    width: 100%;
    font-family: 'Ubuntu';
    font-size: 15px;
    font-style: normal;
    font-weight: 400;
    line-height: normal;
    color: #333;
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table tr:first-of-type {
    height: 35px;
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table th.left {
    padding-top: 40px;
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table .left {
    text-align: left;
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table th {
    background-color: white;
    font-weight: bold;
    text-align: center;
    font-family: 'Ubuntu';
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table th,
#muscle-invasive__safety #safety-main-container .adverse-reactions__table td {
    border: 1px solid #ddd;
    padding: 4px;
    text-align: left;
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table td:first-child, 
#muscle-invasive__safety #safety-main-container .adverse-reactions__table th:first-child {
    border-left: none;
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table th {
    background-color: white;
    font-weight: bold;
    text-align: center;
    font-family: 'Ubuntu';
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table td:last-child, 
#muscle-invasive__safety #safety-main-container .adverse-reactions__table th:last-child {
    border-right: none;
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table .red-text,
#muscle-invasive__safety #safety-main-container .color-red {
    color: #C0403A;
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table .red-text {
    font-weight: 700;
    font-family: 'Ubuntu';
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table .subheader-cell {
    border-top: none;
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table .light-background {
    background-color: #EDF0F8 !important;
    width: 18%;
}


#muscle-invasive__safety #safety-main-container .adverse-reactions__table-wrapper sup {
    font-family: Arial;
    font-size: 65%;
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table th.subheader-cell:last-child {
    font-family: 'Ubuntu';
    font-weight: 400;
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table .category {
    font-weight: 700;
    color: #4D4D4F;
    background-color: white;
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table td:first-child {
    width: 192px;
    white-space: nowrap;
    max-width: 192px;
}

#muscle-invasive__safety #safety-main-container td.category {
    font-family: 'Ubuntu';
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table .centered {
    text-align: center;
}

#muscle-invasive__safety #safety-main-container .footnote {
    margin: 25px 0 3px;
}

#muscle-invasive__safety #safety-main-container .footnote p {
    font-family: 'Ubuntu', sans-serif;
    font-size: 12px;
    font-style: normal;
    font-weight: 400;
    line-height: 16px;
    margin: 0;
    color: #555;
}

#muscle-invasive__safety #safety-main-container .hide,
#muscle-invasive__safety #safety-main-container .mobile-only,
#muscle-invasive__safety #safety-main-container .mobile-only1 {
    display: none;
}

#muscle-invasive__safety #safety-main-container ul.list {
    padding: 0 0 0 24px;
    margin: 34px 0;
}
#muscle-invasive__safety #safety-main-container ul.list.mb-0 {
    margin: 34px 0 37px;
}

#muscle-invasive__safety #safety-main-container .list li {
    font-family: 'Ubuntu', sans-serif;
    font-size: 16px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    color: #555;
    list-style-type: none;
    text-indent: -8px;
    margin-left: 2px;
    letter-spacing: -0.1px;
    position: relative;
}

#muscle-invasive__safety #safety-main-container .list li:before {
    left: -6px;
    position: relative;
    line-height: normal;
    content: url(/content/dam/intelligentcontent/brands/imfinzi-hcp/us/en/bladder-cancer/images/global/bullet-marker.svg);
    width: 6px;
    height: 6px;
    display: inline-block;
    font-size: 16px;
    top: 3px;
}

#muscle-invasive__safety #safety-main-container .list.mb-0 ul,
#muscle-invasive__safety #safety-main-container .list.list-mt ul {
    padding: 8px 30px 0 24px;
    display: flex;
    flex-direction: column;
    gap: 3px;
}

#muscle-invasive__safety #safety-main-container .list li ul li {
    font-weight: 400;
    padding-bottom: 3px;
}

#muscle-invasive__safety #safety-main-container .list li ul li:before {
    color: #555555;
    content: '-';
    left: -2px;
    top: 2px;
    font-size: 20px;
    line-height: 0;
    visibility: visible;
}

#muscle-invasive__safety #safety-main-container ul.list.list-mt {
    margin-bottom: 0;
    padding-bottom: 76px;
}

#muscle-invasive__safety #safety-main-container .dr-content {
    display: flex;
    align-items: center;
    justify-content: normal;
    padding: 20px;
}
#muscle-invasive__safety #safety-main-container .dr-content sup{
    font-size:60%;
}

#muscle-invasive__safety #safety-main-container .dr-content h3 {
    font-family: 'Ubuntu', sans-serif;
    font-size: 42px;
    font-style: normal;
    font-weight: 700;
    line-height: 22px;
    margin: 0;
}
#muscle-invasive__safety #safety-main-container .dr-content h3.color-red {
    color: #AC182E
}

#muscle-invasive__safety #safety-main-container .dr-content h3:not(.color-red) {
    color: #003865;
}

#muscle-invasive__safety #safety-main-container .dr-content p {
    font-family: Ubuntu;
    font-size: 16px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    margin: 0 0 0 15px;
    color: #555
}

#muscle-invasive__safety #safety-main-container .list.mar28 {
    margin-top: 17px !important;
}

#muscle-invasive__safety #safety-main-container .list.list1 li,
#muscle-invasive__safety #safety-main-container .list.mar28 li {
    font-weight: 400;
}

#muscle-invasive__safety #safety-main-container .list.list1.mar43 {
    margin: 14px 0 25px;
}

#muscle-invasive__safety #safety-main-container #discontinuation-rates .box-title span {
    position: relative;
}

#muscle-invasive__safety #safety-main-container #discontinuation-rates .footnote {
    padding-bottom: 30px;
}

#muscle-invasive__safety #safety-main-container .footnote.footnote1 {
    margin-left: 13px;
    margin-bottom: 0px;
}

#muscle-invasive__safety #safety-main-container .footnote.footnote1 p {
    padding-right: 10px;
    padding-bottom: 3px;
}

#muscle-invasive__safety #safety-main-container .footnote.footnote1 p:first-child {
    text-indent: -5px;
}

#muscle-invasive__safety #safety-main-container #discontinuation-rates .footnote p:last-child {
    padding-bottom: 3px;
}

#muscle-invasive__safety #safety-main-container #discontinuation-rates h2 {
    margin: 40px 0 45px;
}

#muscle-invasive__safety #safety-main-container #laboratory-abnormalities .button + .text .cmp-text {
    margin-top: 60px;
}

#muscle-invasive__safety #safety-main-container #laboratory-abnormalities .box-title {
    font-size: 16px;
}

#muscle-invasive__safety #safety-main-container #laboratory-abnormalities .footnote p {
    text-indent: -3px;
}

#muscle-invasive__safety #safety-main-container #laboratory-abnormalities .footnote p:first-child {
    text-indent: -8px;
    margin-left: 4px;
}

#muscle-invasive__safety #safety-main-container #laboratory-abnormalities ul.list.list1 {
    margin-top: 20px;
}

#muscle-invasive__safety #safety-main-container .switch-section {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: 35px 5px 64px 38px;
    max-width: 758px;
}

#muscle-invasive__safety #safety-main-container .switch-before,
#muscle-invasive__safety #safety-main-container .switch-after {
    font-size: 16px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    color: #003865;
    font-family: 'Ubuntu';
    margin-left: 15px;
}

#muscle-invasive__safety #safety-main-container .switch-before img,
#muscle-invasive__safety #safety-main-container .switch-after img {
    vertical-align: sub;
    padding-right: 5px;
}

#muscle-invasive__safety #safety-main-container .switch-after img {
    transform: rotate(180deg);
}

#muscle-invasive__safety #safety-main-container .aem-Grid > .container:last-child {
    margin-bottom: 42px;
}

#muscle-invasive__safety #safety-main-container .adverse-reactions__table.laboratory-abnormalities__table td:first-child {
    white-space: normal;
    width: 206px;
    max-width: 206px;
}

#muscle-invasive__safety #safety-main-container #laboratory-abnormalities .button + .text + .text {
    margin: 0 auto 42px;
}
#muscle-invasive__safety .section-reference .reference {
        color: #4A4A4A   
}

@media screen and (max-width: 991px) {

    #muscle-invasive__safety #safety-main-container {
        background: #fff;
    }

    #muscle-invasive__safety .experiencefragment + .container .cmp-container .aem-Grid .cmp-container .text {
    padding: 0;
}

    #muscle-invasive__safety #safety-main-container .mobile-only, #muscle-invasive__safety #safety-main-container .mobile-only1 {
        display: block;
    }

    #muscle-invasive__safety #safety-main-container .mobile-only1.hand-icon {
        display: none;
    }
    
    #muscle-invasive__safety .mobile-menu .cmp-text {
        padding: 0;
    }

    #muscle-invasive__safety .experiencefragment + .container {
        margin-top: 101px;
    }

    #muscle-invasive__safety #safety-main-container .title h1,
    #muscle-invasive__safety #safety-main-container .aem-Grid > .title + .text,
    #muscle-invasive__safety #safety-main-container .azcl-container.aem-GridColumn,
    #muscle-invasive__safety #safety-main-container .aem-Grid > .container {
        padding: 0 15px;
    }

    .muscle-invasive-bladder-cancer #blue-bar-wrap p {
        font-size: 14px;
        line-height: 16px;
        padding: 5px 5px 5px 15px;
        text-align: start;
        margin-top: 3px;
    }

    #muscle-invasive__safety #safety-main-container #grey-head p {
        font-size: 16px;
        line-height: 20px;
        margin: 0 0 15px;
        letter-spacing: -0.52px;
    }

    #muscle-invasive__safety #safety-main-container #adverse-reactions .button {
        overflow: hidden;
        padding: 0 15px 5px;
    }

    #muscle-invasive__safety #safety-main-container h2 {
        margin: 37px 0 45px;
    }

    #muscle-invasive__safety #safety-main-container .box-title {
        padding: 0 0 0 10px;
        line-height: 16px;
        width: 92%;
    }
    #muscle-invasive__safety #safety-main-container #discontinuation-rates .box-title {
        padding: 0 0 0 10px;
        line-height: 22px;
        width: 95%;
        letter-spacing: -0.45px;
    }
    
    #muscle-invasive__safety #safety-main-container #adverse-reactions .box-title {
        width: 90%;
    }

    #muscle-invasive__safety #safety-main-container .adverse-reactions__table-wrapper {
        overflow-x: scroll;
        position: relative;
        max-width: 100%;
        -webkit-overflow-scrolling: touch;
        scrollbar-width: none;
    }

    #muscle-invasive__safety #safety-main-container .adverse-reactions__table-wrapper::-webkit-scrollbar {
        display: none;
    }

    #muscle-invasive__safety #safety-main-container .adverse-reactions__table {
        width: 100%;
        border-collapse: separate;
        border-spacing: 0;
    }

    #muscle-invasive__safety #safety-main-container .adverse-reactions__table th[rowspan="2"],
    #muscle-invasive__safety #safety-main-container .adverse-reactions__table td:first-child {
        box-shadow: 2px 0 5px rgba(0, 0, 0, 0.1);
    }

    #muscle-invasive__safety #safety-main-container .adverse-reactions__table th[rowspan="2"] {
        z-index: 4;
        text-align: left;
    }

    #muscle-invasive__safety #safety-main-container .adverse-reactions__table th[rowspan="2"], 
    #muscle-invasive__safety #safety-main-container .adverse-reactions__table td:first-child {
        left: 0;
        z-index: 3;
        background: white;
        min-width: 200px;
        max-width: 200px;
    }

    #muscle-invasive__safety #safety-main-container .adverse-reactions__table th, 
    #muscle-invasive__safety #safety-main-container .adverse-reactions__table td {
        white-space: nowrap;
    }

    #muscle-invasive__safety #safety-main-container .adverse-reactions__table td.category,
    #muscle-invasive__safety #safety-main-container .adverse-reactions__table tr:nth-child(1) th:first-child,
    #muscle-invasive__safety #safety-main-container .adverse-reactions__table td:first-child {
        position: sticky;
        left: 0;
        z-index: 1;
        background: white;
        white-space: break-spaces;
    }

    #muscle-invasive__safety #safety-main-container .hscroll-bar {
        margin-top: 20px;
        height: 10px;
        overflow: hidden;
        position: relative;
        white-space: nowrap;
        transform: rotate(180deg);
        margin-bottom: 10px;
        border: 1px solid #808184;
      }

    #muscle-invasive__safety #safety-main-container .hscroll-thumb {
        cursor: grab;
        touch-action: none;
        height: 10px;
        position: absolute;
        background: #808184;
    ;
        left: 0;
    }

    #muscle-invasive__safety #safety-main-container .hscroll-thumb:active {
        cursor: grabbing;
    }

    #muscle-invasive__safety #safety-main-container .hscroll-thumb span {
        position: absolute;
        height: 10px;
        background: #808184;
    }

    #muscle-invasive__safety #safety-main-container ul.list {
        margin: 46px 0;
    }

    #muscle-invasive__safety #safety-main-container .mb-0 {
        margin-bottom: 0;
    }

    #muscle-invasive__safety #safety-main-container ul.list.list-mt {
        padding-bottom: 122px;
    }

    #muscle-invasive__safety #safety-main-container #discontinuation-rates h2 {
        margin: 25px 0 -10px;
    }

    #muscle-invasive__safety #safety-main-container .list.mar28 {
        margin-top: 17px;
        margin: 28px 0 40px;
    }

    #muscle-invasive__safety #safety-main-container .dr-content {
        justify-content: center;
        padding: 32px 0px 14px 0px;
        flex-direction: column;
        gap: 35px;
    }

    #muscle-invasive__safety #safety-main-container .dr-content h3 {
        font-size: 80px;
    }

    #muscle-invasive__safety #safety-main-container .dr-content p {
        margin: 0;
    }

    #muscle-invasive__safety #safety-main-container .dr-content h3 sup {
        font-size: 54%;
    }

    #muscle-invasive__safety #safety-main-container .footnote {
        margin: 35px 0 13px;
    }

    #muscle-invasive__safety #safety-main-container .footnote p {
        font-size: 10px;
        align-items: baseline;
        padding-right: 16px;
    }
    #muscle-invasive__safety #safety-main-container .footnote.footnote2 p{
        text-indent: -4px;
    }
    #muscle-invasive__safety #safety-main-container .footnote.footnote1 {
        margin-left: 0px;   
    }
    #muscle-invasive__safety #safety-main-container #laboratory-abnormalities .footnote p {
        padding-right: 6px;   
    }

    #muscle-invasive__safety #safety-main-container #laboratory-abnormalities .box-title {
        line-height: normal;
        max-width: 300px;
        padding: 0 0 0 15px;
    }
   
    #muscle-invasive__safety #safety-main-container #laboratory-abnormalities .adverse-reactions__table-wrapper.content-box-image--wrapper {
        margin-top: 49px;
    }

    #muscle-invasive__safety #safety-main-container .adverse-reactions__table tr:nth-child(1) th:first-child {
        line-height: 8px;
    }

    #muscle-invasive__safety #safety-main-container .adverse-reactions__table th[rowspan="2"],
    #muscle-invasive__safety #safety-main-container .adverse-reactions__table td:first-child {
        box-shadow: 2px 0 5px rgba(0, 0, 0, 0.1);
    }

    #muscle-invasive__safety #safety-main-container #laboratory-abnormalities .hr-scroll-txt + .footnote {
        margin-bottom: 0;
    }

    #muscle-invasive__safety #safety-main-container #laboratory-abnormalities .list.list1 + .footnote p {
        padding-right: 0;
    }

    #muscle-invasive__safety #safety-main-container #laboratory-abnormalities .button + .text + .text {
        max-width: 883px;
        padding: 55px 0 60px;
        background: #FFF;
    }

    #muscle-invasive__safety #safety-main-container .switch-section {
        padding-left: 7px;
        padding-right: 22px;
        max-width: 100%;
    }
    
    #muscle-invasive__safety #safety-main-container ul.list.mb-0 {
        margin: 44px 0 37px;
    }
    #muscle-invasive__safety #safety-main-container #discontinuation-rates .text .footnote.footnote1 p:last-child> sup{
        font-size: 64%;
    }
    #muscle-invasive__safety #safety-main-container #discontinuation-rates .footnote {
        padding: 10px 0 30px 14px;
    }

}

@media screen and (max-width: 767px) {

    #muscle-invasive__safety #safety-main-container #laboratory-abnormalities .button + .text + .text,
    #muscle-invasive__safety #safety-main-container .aem-Grid > .container:last-child {
        margin: 0;
    }

    #muscle-invasive__safety #safety-main-container .mobile-only1.hand-icon {
        display: block;
        position: absolute;
        top: 54%;
        left: 34%;
        width: 91px;
        z-index: 1;
    }

    #muscle-invasive__safety #safety-main-container .content-box {
        margin-top: 40px;
    }

    #muscle-invasive__safety #safety-main-container .adverse-reactions__table-wrapper {
        margin-top: 15px;
    }

    #muscle-invasive__safety #safety-main-container .hr-scroll-txt p {
        color: #808184;
        font-family: Ubuntu;
        font-size: 14px;
        font-style: normal;
        font-weight: 700;
        line-height: normal;
        text-transform: uppercase;
        text-align: center;
        margin: 0;
    }

    #muscle-invasive__safety #safety-main-container ul.list.mb-0 li {
        letter-spacing: -0.4px !important;
    }

    #muscle-invasive__safety #safety-main-container ul.list.list-mt {
        padding-bottom: 49px;
        margin: 35px 0 0px;
    }

    #muscle-invasive__safety #safety-main-container ul.list.mb-0 ul {
        padding: 8px 0px 0 24px;
    }

    #muscle-invasive__safety #safety-main-container .list.list-mt ul {
        padding: 4px 0px 0 24px !important;
    }

    #muscle-invasive__safety #safety-main-container ul.list.list-mt ul:before,
    #muscle-invasive__safety #safety-main-container ul.list.mb-0 ul:before{
		top: -42px;
	}

    #muscle-invasive__safety #safety-main-container .list.mar28 {
        margin-top: 28px !important;
    }
    
    #muscle-invasive__safety #safety-main-container .list.list1.mar43 {
        margin-top: 43px !important;
        padding-bottom: 10px;
    }

    #muscle-invasive__safety #safety-main-container .list.list1.mar30 {
        margin-top: 32px !important;
    }

    #muscle-invasive__safety #safety-main-container #adverse-reactions .box-title:before {
        top: 3px;
    }

    #muscle-invasive__safety #safety-main-container #discontinuation-rates .box-title:before {
        top: 7px;
    }

    #muscle-invasive__safety #safety-main-container .footnote.footnote1 p:first-child {
        text-indent: -4px !important;
        margin-left: 0 !important;
    }

}

/*CC*/
@media (min-width:800px) and (max-width:991px){
   #muscle-invasive__safety #safety-main-container .text{
    padding: 0!important;

    max-width: 888px!important;
}
 #muscle-invasive__safety #grey-head {
    margin: 0!important;
    padding: 0px 15px;
}
    
    
}


@media (min-width:320px) and (max-width:375px){
    #muscle-invasive__safety #safety-main-container .adverse-reactions__table-wrapper {
        
        margin-top: 57px !important;
    }
    
    
}


@media (min-width:887px) and (max-width:991px){
        #muscle-invasive__safety #safety-main-container .text {
        max-width: 100%!important;
        }
    
    
}
 
@media (min-width:767px) and (max-width:991px){
        #muscle-invasive__safety #safety-main-container #discontinuation-rates h2 {
        margin: 25px 0 17px!important;
        }
    
    
}

@media (min-width:800px) and (max-width:991px){
    #muscle-invasive__safety #safety-main-container .button + .title{
        
            max-width: 100%!important;
    }
    
}

















div#adverse-reactions,
#discontinuation-rates,
#laboratory-abnormalities {
    scroll-margin-top: 137px;
}